Emerging technologies in reading and writing the epigenome
Covalent modifications of DNA and histones play critical roles in genome regulation, cell activity, development, and disease. In recent years, rapid advances in genomics technologies have enabled unprecedented mapping of the epigenome in a wide range of systems, providing new insights into the roles and dynamics of these modifications. Given the essential role that the epigenome plays in defining cell identity, major efforts are now focused upon profiling the epigenome at single cell resolution, and monitoring the patterns and dynamics of these modifications. Simultaneously, genome editing technologies are rapidly being repurposed to achieve precise editing of epigenomic modifications where desired in the genome, in order to elucidate the causal relationships between these modifications and genome regulation, as artificial regulatory tools, and potentially in the future to remedy aberrant epigenome patterns in disease states.
Dr Ryan Lister
The Harry Perkins Institute of Medical Research and The University of Western Australia
Ryan Lister leads a research group investigating the epigenome and cell identity, at the University of Western Australia and the Harry Perkins Institute of Medical Research. After receiving his PhD from UWA in 2005, Ryan undertook postdoctoral studies at The Salk Institute for Biological Studies, where he developed and applied new techniques to map the epigenome and transcriptome. Ryan’s laboratory at UWA is focused upon understanding how the epigenome patterns are established and changed, how they affect the readout of underlying genetic information, their involvement in development and disease, and developing molecular tools to precisely edit the epigenome.