Success of synthetic bone grants relies on development of manufacturing techniques that offer full control over their chemistry, external shape, and internal architecture, which consequently results in closely controlled mechanical and biochemical properties. For this purpose, we developed a versatile stereolithography 3D printing technique and used it to fabricate human-scale anatomically shaped Baghdadite scaffolds for bone repair. To optimize the mechanical and fluidic properties of the scaffolds, we explored six different internal architectures. The effects of relative orientation of scaffolds with respect to the bone, convexity of surfaces, and isotropicity of the scaffolds on their mechanical and fluidic properties as well as bone ingrowth were determined using a combination of mechanical tests, in-vivo experiments, CT reconstruction, and finite element simulations. The results show that the properties of the bioceramic scaffolds and bone ingrowth within them can be significantly improved by tailoring their internal architecture using our printing technique.
Research Fellow and Lecturer, Biomaterials and Tissue Engineering Research Unit, The University of Sydney
Mohammad Mirkhalaf is a research fellow and lecturer at the University of Sydney (USyd) since September 2018. He finished his Bachelor’s at Isfahan University of Technology (IUT), Master’s at Nanyang technological university (NTU), and PhD at McGill University. After finishing PhD in May 2015, he joined National Research Council of Canada as a postdoctoral fellow working closely with his previous lab at McGill till Aug 2018. He has published 18 original research articles and one invited review article, two book chapters, a full US patent, a patent at PCT stage, a provisional patent, and five full papers in refereed conference proceedings. Of the journal articles, he is the first author on 13; these include publications in leading multidisciplinary journals such as Nature Communications and PNAS, and in leading disciplinary journals in mechanics such as Int J Solids Struct, and Extreme Mechanics Letters. He has won several prestigious awards such as NSERC (Canadian government funding agency) postdoctoral fellowship, FQRNT (Quebec’s government funding agency) postdoctoral award, McGill engineering doctoral award, and A*Star graduate scholarship at NTU. He is currently developing two new courses at USyd, and has also been teaching at McGill, NTU and IUT.